RISK POLYMORPHISMS IN ORAL LEUKOPLAKIA: A SYSTEMATIC REVIEW Alejandra Bono

(1),

Ana María Zarate

(2),

Julieta Don

(2),

José Luis Barra

(3), Mabel

Brunotto

(2)

(1) Departamento de Patología Bucal, Facultad de Odontología. Universidad Nacional de Córdoba - Córdoba – Argentina (2) Departamento de Biología Bucal, Facultad de Odontología. Universidad Nacional de Córdoba - Córdoba – Argentina (3) CIQUIBIC, UNC-CONICET, departamento de Química Biológica, Facultad de Ciencias Químicas. Universidad Nacional de Córdoba- Argentina

Introduction Oral Potentially Malignant Disorders, in general, may be predecessors for the development of oral cancer. The greatest challenge is to predict which potentially malignant oral mucosa disease will be able to progress to oral cancer. One of the most valuable tools for early diagnosis is the recognition of individual risks, which depends on the availability of methodological strategies to identify the profiles of people with a genetic composition of risk. There are many papers about the relationship between genetic polymorphisms and disease. Genome-wide association studies offer a potentially powerful approach for mapping causal genes with modest effects, but are limited because only a small number of genes can be studied at a time. Systematic review is one of the mechanisms for assessing the total effect of a polymorphism and/or gene. The Human Genome Epidemiology Network (HuGENet™) has developed the HuGE reviews, typical systematic reviews on genomic associations. Purpose To identify studied genes in recent years and to know which ones are related to the risk of developing OL. Method Eligible gene/polymorphism studies were identified by lectronic searches. Individual participant data of 2054 Oral Leukoplakia and 3493 controls from 16 genetic studies were analyzed, yielding adjusted (tobacco, gender, age and alcohol) odds ratios (OR) and 95% confidence intervals (CIs) comparing cases with controls. Conclusions According to the results of this work, we conclude that all genotypes are heterozygous or homozygous for the polymorphic variants; and the people with genotypes CYP1A1 m1/m2, XDP Gln/Gln, GSTM1 null, P53 intron 6, XRCC3 rs861539, COX2 -765 have high risk of presented OL, and therefore be more exposed to risk of oral cancer.

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